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Indole-3-Carbinol
I3C is formed from glucobrassicin in broccoli, cabbage, Brussels sprouts and other cruciferous vegetables. In the body it is converted, among other compounds, into DIM.
Plant compounds, scientifically informed
Indole-3-Carbinol for advanced cellular support
A highly concentrated combination of Indole-3-Carbinol (I3C), Resveravine® and resveratrol from Japanese knotweed – for people who value plant-based quality and transparent scientific context.
✓ 800 mg I3C per daily serving
✓ Vegan & non-GMO
✓ Laboratory-tested quality
45,00 €
Buy at medpro →60 capsules · 2-week supply*
From cruciferous vegetables
GMP-oriented production
I3C · RESVERAVINE® · RESVERATROL
Three bioactive plant components
The formula combines I3C from cruciferous vegetables with selected polyphenols. Research mainly explores these compounds in relation to estrogen metabolism, cellular signalling and oxidative stress.
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Resveravine®
A standardised complex containing oligostilbenes and resveratrol. Polyphenols are widely studied for antioxidant and cellular signalling properties.
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Polygonum cuspidatum
Japanese knotweed is a natural source of resveratrol and other secondary plant compounds.
SCIENCE & TRANSPARENCY
What research investigates
Human studies show that I3C can measurably alter estrogen metabolism. At the same time, many broader findings come from cell and animal models. This product is a food supplement, not a medicine intended to treat or prevent disease.
Estrogen metabolismSeveral human studies reported changes in the ratio of selected estrogen metabolites.
TolerabilityPhase I studies found 400–800 mg daily to be well tolerated over limited periods.
Preclinical researchI3C and DIM are being studied across several cellular signalling pathways.
More evidence neededClinical effectiveness for specific diseases has not been conclusively established.
PRODUCT DETAILS
Ingredients & recommended use
4 capsules per daily serving
Take two capsules twice daily with water before meals. Do not exceed the recommended daily intake.
| Ingredient | Daily amount |
|---|---|
| Indole-3-Carbinol | 800 mg |
| Resveravine® (20% oligostilbenes, 6% resveratrol) | 250 mg |
| Polygonum cuspidatum root extract | 10 mg (including 5 mg resveratrol) |
SPECIALIST ARTICLE · INTEGRATIVE ONCOLOGY
I3C as part of an integrative phytotherapy concept
A specialist article by Prof. Dr. Dr. med. Ben L. Pfeifer describes indole-3-carbinol as one component of a broader complementary oncology concept for metastatic breast cancer. I3C was not used on its own, but together with other phytotherapeutic substances and supportive measures.
From cruciferous vegetables to I3C and DIM
Indole-3-carbinol is formed from glucosinolates found in cruciferous vegetables. In the acidic environment of the stomach, compounds including diindolylmethane (DIM) are formed. The article discusses both substances in relation to antioxidant, inflammation-modulating and cellular research pathways.
Pilot and retrospective data
The article reports a small prospective pilot study involving 26 patients and a retrospective evaluation of 268 patients. The observations relate to the complete, individually combined treatment concept and cannot be attributed to I3C alone.
No proof of an isolated effect
The authors explicitly acknowledge methodological limitations. These findings should be viewed as clinical observations and a basis for further research, not as evidence that this food supplement treats or prevents cancer or replaces prescribed medical care.
Literature reference
Pfeifer BL, Fahrendorf T: Indol-3-Carbinol – ein Glucosinolat-Derivat aus Kreuzblütler-Gemüsen. Deutsche Zeitschrift für Onkologie. 2015;47:20–27. The related article “Metastatic breast cancer – a phytotherapy concept offers opportunities” describes I3C within a multimodal protocol.
View further studiesPfeifer BL, Fahrendorf T: Indol-3-Carbinol – ein Glucosinolat-Derivat aus Kreuzblütler-Gemüsen. Deutsche Zeitschrift für Onkologie. 2015;47:20–27. The related article “Metastatic breast cancer – a phytotherapy concept offers opportunities” describes I3C within a multimodal protocol.
Medical notice: People undergoing cancer treatment should only use food supplements after consultation with their oncology team. Potential interactions with medicines and individual treatment plans must be assessed professionally.
PUBMED
Selected scientific studies
The publications below concern Indole-3-Carbinol or I3C-containing combinations. They do not demonstrate a therapeutic effect of this specific product.
2021
Indoles Derived From Glucobrassicin
Review of I3C and DIM, preclinical mechanisms and early clinical evidence.
2005
Phase I study in women
17 women received 400 mg and then 800 mg I3C daily; these doses were well tolerated in this small study.
1998
Dose-ranging estrogen metabolism study
Placebo-controlled study in 60 women at increased breast cancer risk using an estrogen-metabolism biomarker.
1991
Altered estrogen metabolism in humans
Short-term I3C intake changed estrogen hydroxylation in 12 healthy volunteers.
Scientific note: Biomarker studies, metabolic pathways and preclinical models do not prove prevention or treatment of disease. Consult your physician or pharmacist before use if you have a medical condition, are pregnant or breastfeeding, or take medication regularly.
Plant-based quality in a defined concentration
Order Indole-3-Carbinol directly from the medpro online shop.